23 articles - From Friday Nov 25 2022 to Friday Dec 02 2022
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Arthritis Res Ther |
Intra-articular injection choice for osteoarthritis: making sense of cell source-an updated systematic review and dual network meta-analysis. Intra-articular injection of MSCs is associated with more effective pain alleviation and function improvement than cell-free OA treatment. However, the potential complications induced by MSCs should be emphasized. A comparative analysis of the MSC sources showed that ADMSCs and UBMSCs exerted a better anti-arthritic efficacy than BMMSCs. Schematic illustration of MSC-based intra-articular injection for treating OA. Three major MSCs (UBMSCs, ADMSCs, and BMMSCs) are extracted and expanded in vitro. Subsequently, the amplified MSCs are concentrated and injected into the knee joint to treat OA. |
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Impact of vaccination on postacute sequelae of SARS CoV-2 infection in patients with rheumatic diseases. Vaccinated patients with SARDs were less likely to experience PASC compared with those not fully vaccinated. While we cannot rule out the possibility that findings may be due to intrinsic differences in PASC risk from different SARS-CoV-2 variants, these findings support the benefits of vaccination for patients with SARDs and suggest that the immune response to acute infection is important in the pathogenesis of PASC in patients with SARDs. |
Reducing cardiovascular risk with immunomodulators: a randomised active comparator trial among patients with rheumatoid arthritis. We found that addition of either a TNFi or triple therapy resulted in clinically important improvements in vascular inflammation. However, the addition of a TNFi did not reduce arterial inflammation more than triple therapy. |
| Arthritis Care Res (Hoboken) |
Agreement Among Multiple Observers on Crystal Identification by Synovial Fluid Microscopy. Compensated polarized microscopy remained consistent in detecting and identifying crystals in synovial fluid, even when examined among multiple observers, confirming its high utility for clinical practice. |
| Arthritis Res Ther |
Abnormal cortical thickness and structural covariance networks in systemic lupus erythematosus patients without major neuropsychiatric manifestations. Extensive and obvious reduction in cortical thickness and abnormal topological organization of SCNs are observed in non-NPSLE patients. The observed abnormalities may not only be the realization of brain damage caused by the disease, but also the contribution of the compensatory changes within the nervous system. |
Four emerging immune cellular blood phenotypes associated with disease duration and activity established in Psoriatic Arthritis. Four immune cellular phenotypes of PsA were suggested at baseline demonstrating complex immune cellular mechanisms in PsA implying the possibility of improving PsA patient stratification based on both clinical and immune cellular phenotypes. |
| Arthritis Rheumatol |
Impaired efferocytosis by synovial macrophages in patients with knee osteoarthritis. Apoptotic cells accumulate in the synovium of patients with late-stage knee OA. Our results suggest that OA impairs critical homeostatic functions of synovial macrophages leading to accumulation of apoptotic cells. |
Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. These findings indicate that Syk plays a critical role in MPO-ANCA IgG-induced myeloid cell responses and that Syk is activated in circulating immune cells and tissue immune cells in AAV; therefore, Syk inhibition may be a potential therapeutic option. |
| Rheumatology (Oxford) |
Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis. Anti-PAD4 and anti-PAD3 antibodies identify RA-patient with higher radiographic injury and bone erosions. In our cohort, ILD is associated with lower radiographic and erosive damage, as well as low levels of anti-PAD4 antibodies. |
Is the relationship between deprivation and outcomes in rheumatoid arthritis mediated by body mass index? A longitudinal cohort study. People with RA living in deprived areas have a higher burden of disease, which is partly mediated through obesity. Weight-loss strategies in RA could be better targeted towards those living in deprived areas. |
Ocular manifestations of ANCA-associated vasculitis. Ocular manifestations occur in al forms of AAV, especially in GPA. Clinicians should be mindful of the wide spectrum of ocular disease in AAV, caused by active vasculitis, disease-associated damage, and toxicities of therapy. |
Prevalence and predictors of atlanto-axial subluxation in rheumatoid arthritis after 12-years' follow-up (ESPOIR Cohort). In conclusion, the prevalence of aAAS after 12 |
Rituximab-treated rheumatic patients: B-cells predict seroconversion after COVID-19 boost or revaccination in initial vaccine non-responders. Continuously impaired humoral response to mRNA vaccines was found in most RTX treated patients after a booster dose or revaccination. Seroconversion was observed in approximately one-third of the patients. Measurable B-cells before boosting or revaccination was the strongest predictor of antibody response after boost or revaccination. |
Symptomatic myopathies in sarcoidosis: disease spectrum and Myxovirus resistance protein A (MxA) expression. Symptomatic myopathy occurred in 0.36% of sarcoidosis. IBM was the second most common cause of myopathies after SM. Frequency of IBM in sarcoidosis is higher than general population. Recognition of features suggestive of alternative etiologies can guide proper treatment. Our findings of abnormal MxA expression warrants a larger study. |
Therapeutic consequences in patients with both inflammatory rheumatic diseases and multiple sclerosis. In this review, we summarize the link between MS and the IRD and the impact of DMARDs on MS, especially TNFi. We also look at the impact of disease-modifying drugs for adults with MS on IRD. |
Utility of nailfold capillary assessment for predicting psoriatic arthritis based on a prospective observational cohort study. NFC abnormalities were suggested to be a predictor of PsA in psoriasis patients, and at the same time, its degree could be an indicator of disease severity. |
Plenty of the editorials are available as full text through the publisher website using the provided link
misc publications eg case reports, tools of the trade, images of the month, etc…
| Ann Rheum Dis |